Metformin Hydrochloride
Product Name: Metformin Hydrochloride
Synonyms: Metformin HCL;3-(diaminomethylidene)-1,1-dimethylguanidine hydrochloride (1:1); 1,1-dimethylbiguanide hydrochloride
CAS: 1115-70-4
MF: C4H12ClN5
MW: 165.62
EINECS: 214-230-6
Assay: 99%
Appearance: White crystals or white crystalline powder
Chemical Property: Soluble in water, dissolved in methanol, slightly soluble in ethanol, insoluble in ether and chloroform. Odorless, bitter taste.
Usage:
Metformin is a biguanide oral hypoglycemic agents, also known as metformin hydrochloride, Glucophage, metformin, phenformin hypoglycemic effect than to be weak, the main role is to reduce the A cell glucagon secretion, promote the conversion of glucose to glycogen, which can not stimulate islet beta cell insulin secretion.
The mechanism of hypoglycemic:
1 increase the sensitivity in the peripheral tissues to insulin, increased insulin mediated glucose utilization.
2 increase the use of non insulin dependent tissue glucose, such as brain, blood cells, renal medulla, gut, skin etc..
3 inhibition of hepatic gluconeogenesis, reduce hepatic glucose output.
4 inhibition of intestinal wall cells and glucose uptake.
5 inhibition of cholesterol biosynthesis and storage, reduce blood triglyceride, total cholesterol levels.
Packing: 25kg/drum
