Basic Info
Product Name: Chlormadinone Acetate
Synonyms: 17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione;
17-Acetoxy-6-chloro-6-dehydroprogesterone;17-alpha-Acetoxy-6-chloro-6,7-dehydroprogesterone;
17-alpha-acetoxy-6-chloro-6-dehydroprogesterone;17alpha-Acetoxy-6-chloro-6-dehydroprogesterone;
17-alpha-acetoxy-6-chloropregna-4,6-diene-3,20-dione;17alpha-Acetoxy-6-chloropregna-4,6-diene-3,
20-dione;20-dione,17-(acetoxy)-6-chloro-pregna-6-diene-3
Suitable for: Elderly, Adult
Purity: >99%
CAS: 302-22-7
Appearance: White Powder
Molecular Formula: C23H29ClO4
Molecular Weight:404.93
EINECS:206-118-0
Fuction: Female Sex Hormone
Usage: Potent progesterone,Orally active progesteron with antiandrogenic activity; has been used in combinations as an oral contraceptive. Progestogen; antineoplastic (hormonal).
Shipping: EMS, HKEMS, FEDEX, DHL, UPS, Aramex, ETC
Delivery Time: 3-5 Working Days Door to Door
Transport Package: Disguised package; Foil bag
Origin: China
Certification: ISO 9001, USP, GMP
Storage: Cool Dry Place
Payment: Western Union, Money Gram, Bank Transfer, Bitcoin
Reship Policy: Reship for Fee
HS Code: 2937290019
Description:
Chlormadinone acetate (CMA) is a derivative of progesterone (17-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione), first synthesized in 1961 and is used as an orally effective progestogen in hormone replacement therapy (HRT), and in combination with ethinyl estradiol (EE) in contraception since 1999. Chlormadinone acetate has a strong progestogenic effect about one-third higher than that of progesterone and may vary depending on the previous effect of an estrogen, i.e., estrogens may promote the formation of progesterone receptors and proliferation of the endometrium. Like progesterone, it is anti-estrogenic and has no partial androgenic effect (at the doses used for contraception and HRT). In contrast to progesterone, it has a slight glucocorticoid effect, a pronounced anti-androgenic effect and no anti-mineralocorticoid effect. No pregnancy-maintaining effect of CMA has been demonstrated in humans.
The anti-androgenic effect of CMA is presumed to be the result of both its binding to androgen receptors competitively inhibiting the effect of endogenous testosterone and dihydrotestosterone and the competitive inhibition of 5-reductase. In this respect, dosing of CMA is crucial; agonistic effects are observed when doses are increased from those optimal for an antagonistic effect.
Chlormadinone acetate has a strong anti-gonadotropic effect, through negative feedback on gonadotropin secretion, and has been used for more than 20 years alone for contraception in arterial risk patients. The clinical and metabolic
