Description:
Pregnenolone and its sulfate, like DHEA and its sulfate and progesterone, belong to the group of neurosteroids that are found in high concentrations in certain areas of the brain, and are synthesized there. Neurosteroids affect synaptic functioning, are neuroprotective, and enhance myelinization. Pregnenolone and its sulfate ester are under investigation for their potential to improve cognitive and memory functioning. Pregnenolone is also being considered as a potential treatment for schizophrenia.
Interestingly, unlike pregnenolone, pregnenolone sulfate is a negative allosteric modulator of the GABAA receptor as well as a positive allosteric modulator of the NMDA receptor. In addition, it has been shown to activate the transient receptor potential M3 (TRPM3) ion channel in hepatocytes and pancreatic islets causing calcium entry and subsequent insulin release.
Pregnenolone, a molecule produced by the brain, acts as a natural defense mechanism against effects of cannabis/marijuana in animals. Pregnenolone prevents THC/Tetrahydrocannabinol, the main active principle in cannabis, from fully activating its brain receptor, the CB1 receptor, that when overstimulated by THC/Tetrahydrocannabinol causes the intoxicating effects of cannabis/marijuana.
Application:
Pregnenolone is used for fatigue and increasing energy; Alzheimer's disease and enhancing memory; trauma and injuries; as well as stress and improving immunity.
It is also is used for skin disorders including psoriasis and scleroderma.
Women use pregnenolone for lumpy breasts (fibrocystic breast disease), a disorder of the lining of the uterus (endometriosis), symptoms of menopause, andpremenstrual syndrome (PMS).
Some people use pregnenolone for slowing or reversing aging, arthritis, anddepression. It is also used for strengthening the heart, allergic reactions, "detoxification," lupus, multiple sclerosis (MS), prostate problems, and seizures.
Usage:
The appropriate dose of pregnenolone depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for pregnenolone. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
